Targeting telomerase with radiolabeled inhibitors
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چکیده
منابع مشابه
Targeting telomerase with radiolabeled inhibitors
The expression of telomerase in approximately 85% of cancers and its absence in the majority of normal cells makes it an attractive target for cancer therapy. However the lag period between initiation of telomerase inhibition and growth arrest makes direct inhibition alone an insufficient method of treatment. However, telomerase inhibition has been shown to enhance cancer cell radiosensitivity....
متن کاملTelomerase inhibitors.
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches...
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During the past 50 years, the development and widespread use of antibiotics, vaccines, and other antimicrobial agents has dramatically reduced the mortality caused by infectious agents. These therapeutic successes were achieved, in large part, by the identification and development of approaches that target molecules expressed exclusively by microbes. This paradigm not only continues to drive ef...
متن کاملTherapeutic Targeting of Telomerase
Telomere length and cell function can be preserved by the human reverse transcriptase telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is normally restricted to cells needing a high proliferative capacity, such as stem cells. Consequently, telomerase-based therapies to elongate short telomeres are developed, some of which have successfully reached the stage I...
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OBJECTIVE Carbonic anhydrase 9 recognized by chimeric monoclonal antibody cG250 is overexpressed on biliary cancers. The aim of this study was to determine the targeting of radiolabeled cG250 in patients with biliary cancer to explore a potential role of radioimmunotherapy. METHODS Three (3) patients received a diagnostic dose 111In-cG250, and images were acquired 2 hours and 5 days after inj...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2017
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2016.09.028